The Mechanism of Glycolysis in the Senescent of Vascular Endothelial Cells
SU Jianfei1, DONG Ying2, ZANG Yi2, LI Jia1,2*
Cellular senescence is a crucial link in the process of cellular life, referring to the gradual degradation of cell proliferation and physiological functions over time during the execution of life activities. Cellular senescence is characterized by permanent cell proliferation arrest and various phenotypic changes, including the release of many bioactive molecules, collectively known as the SASP (senescence-associated secretory phenotype). Senescent vascular endothelial cell is an important triggering factor for many cardiovascular and metabolic related diseases. Given that changes in glycolysis can lead to dysfunction of endothelial cell function and angiogenesis, changes in glycolytic flux caused by endothelial senescence are closely related to many pan vascular diseases. This review summarizes the changes and mechanisms of glycolytic flux in endothelial cell senescence, as well as the impact of targeted glycolysis on endothelial senescence, providing reference and support for addressing endothelial senescence-related diseases from the perspective of glucose metabolism.
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