Current Research Progress of Lung Fibroblasts in the Repair of Lung Injury
YANG Di, ZHANG Jiazhu, SUI Pengfei*
Fibroblasts are crucial components of lung interstitial cells, which provide extracellular matrix to maintain tissue architecture and serve as a functional niche for lung stem cells. Through paracrine signaling, fibroblasts communicate with multiple cell types, which is critical for preserving tissue integrity during homeostasis and regeneration following injury. Aberrant activated fibroblasts are frequently detected under pathological conditions, resulting in excessive deposition of matrix and participating in progression of lung diseases by secreting collagen and fibronectin. As the significance of fibroblasts in maintaining lung homeostasis and regeneration, this review systematically summarizes recent advances in lung fibroblast research. Moreover, this review proposes future directions of lung fibroblast research, addressing these remaining questions may provide novel insights into understanding the mechanisms of lung diseases and identifying potential therapeutic targets.
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