The Roles and Mechanisms of MSTN in the Developments of Obesity and Diabetes Mellitus and the Regulation of Exercise on MSTN
HE Yong1, FU Shaoting2, WANG Xiaohui1*
In addition to negatively regulate skeletal muscle mass, MSTN (myostatin) also plays an important role in the occurrence and development of obesity and diabetes. In obese and diabetic patients, serum MSTN content and the expression level of MSTN in skeletal muscle are significantly increased, and reducing MSTN expression or inhibiting its activity reduces fat accumulation in body and delay the occurrence and development of obesity and diabetes. The inhibition of MSTN expression or activity delays the development of obesity and diabetes, which is achieved not only by increasing skeletal muscle mass, but also by increasing glucose uptake, promoting adipocyte development, metabolism and browning of white adipose tissue, improving leptin sensitivity, reducing inflammatory response, and improving mitochondrial function and so on. Exercise can also reduce the level of MSTN in obese and diabetic patients, which may be one of the mechanisms about exercise reducing fat, improving insulin sensitivity, reducing blood glucose and lipid, and thus preventing the occurrence and development of obese and diabetes. This review focuses on the effects and mechanisms of MSTN in obesity and diabetes, as well as its regulation by exercise, which provides a new target for prevention and treatment of obesity and diabetes, and a new perspective about the mechanisms of the improvement of obesity and diabetes by exercise.
CN
EN