Research Progress on the Effect of Mitochondria-Mediated Energy Metabolism on Repair of Central Nerve System Injury
ZHOU Mei, ZHANG Yanren, WEI Tao, CAI Shufang, WU Yanqing*
Mitochondria-mediated energy metabolism is closely related to the repair of CNS (central nerve system) injury. CNS injury will lead to mitochondrial damage, reduce the mitochondrial transport, depolarize the local mitochondria, and result in ATP loss and energy deficiency of local axons. Thus, a guarantee of number of healthy mitochondria and effective regulation of mitochondrial transport and orientation are important for satisfying the energy need of CNS repair. This paper reviews the energy requirement of nerve cells and dynamic changes of mitochondria after CNS injury, and analyzes the relationship between mitochondrial function and CNS repair. Lastly, it summarizes the related research progress of mitochondrial-related strategies for promoting the repair of CNS injury. This review aims to provide new ideas for clinically promoting CNS injury repair.
CN
EN