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The Phenotypes and Functions of Type 1 Regulatory T cells
Qing Ding, Kuang-Yen Chou*
Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine;E-Institute of Shanghai Universities, Immunology Division, Shanghai 200025, China
Abstract: CD4+ type-1 regulatory T (Tr1) cells have an essential role in the induction and maintenance of tolerance to foreign and self-antigens， and they have been extensively characterized in mice and humans. Tr1 cells produce high levels of IL-10 and mediate IL-10-dependent suppression， whereas the effects of CD4+CD25+ Tr cells appear to be cell-contact-dependent. Tr1 cells arise in periphery upon encountering antigen in a tolerogenic environment. We have been interested in defining the characters of Tr1 cells， with the ultimate aim of designing therapeutic strategies to harness their immunoregulatory effects. This review discussed the phenotypes and functions of Tr1 cells， and the similarities and differences between Tr1 cells and CD4+CD25+ Tr cells.
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