Research Progress of Intestinal Flora and Exosomes and Their Synergistic Effects on Bone Homeostasis
QI Xin1, LIU Jianjun2*, ZHANG Xiaogang2*, CHEN Xin2, ZHAO Xiyun2, WANG Zhipeng2, CHEN Yixin1, LI Jinfeng1, LIU Shuo1
Bone homeostasis is based on the dynamic balance of osteoblast and osteoclast metabolism, which is crucial to the progress of metabolic diseases in orthopedics such as osteoporosis, osteoarthritis and femoral head necrosis. With the development of cellular biomolecular engineering, the study of intestinal flora or exosomes has become a hot spot in the prevention or treatment of bone metabolism-related diseases. There are many studies on immune regulation, inflammatory response, apoptosis, bone metabolism and homeostasis. At present, there are few studies on the regulation of diseases based on the synergistic effect of intestinal flora and exosomes, and the exploration of bone metabolism related diseases is limited. Through consulting relevant literature, the authors believe that intestinal flora is correlated with exosomes, and may have high research value in the treatment of orthopedic diseases. Therefore, this paper reviews the latest research progress on the effects of intestinal flora, exosomes and their synergistic effects on bone homeostasis, in order to provide new ideas and basis for clinical treatment of bonerelated diseases.
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