Role and Mechanism of the Double-Stranded RNA-Binding Protein STAUFEN1 in the Differentiation of Adipocyte
JIANG Shuo, LIU Dihui, MENG Xuanyu, CHEN Siyuan, LIANG Xiaodi*
Obesity caused by excessive energy intake has become a worldwide problem, posing a serious threat to people’s health. Obesity is characterized by excessive deposition of fat in some parts, and the excessive proliferation and abnormal differentiation of fat cells are the basis of obesity. More and more studies have shown that posttranscriptional regulation plays an important role in adipocyte differentiation. STAU1 (STAUFEN1) is a double-stranded RNA binding protein that can specifically mediate the degradation of target mRNA and participate in adipocyte differentiation. STAU1 can regulate the alternative splicing, translation and degradation of adipocyte differentiation related genes at the post transcriptional level, thereby affecting mRNA metabolism. This paper reviews the function and mechanism of STAU1 in adipocytes and tissues, hoping to provide new enlightenment for the treatment of obesity and type 2 diabetes.
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