Research Progress of Nitric Oxide in Regulating the Decline of Erythrocyte Deformability Induced by Exhaustive Exercise
QI Qinke, WANG Dan, LI Zongxiang, LIU Yanzhong, LAN Linfei, LIU Yiping*
The deformability of RBC (red blood cell) plays an important role in ensuring the normal function of oxygen transport. Exhaustive exercise leads to hypoxia, oxidative stress reaction, oxidation-reduction instability and destruction of erythrocyte membrane structure. Hemoglobin will also be oxidized to methemoglobin, which will be cross-linked with erythrocyte membrane skeleton protein and eventually lead to the decline of erythrocyte deformability. Nitric oxide can not only participate in the regulation of blood flow homeostasis as an endothelial relaxing factor, but also has been found to have the function of regulating erythrocyte deformability in recent years. This article takes the regulation of nitric oxide on the oxidative damage reaction of erythrocyte membrane as the starting point, and combs the mechanism of nitric oxide regulating the decline of erythrocyte deformability induced by exhaustive exercise, in order to provide a theoretical basis for promoting the recovery of oxygen transport function after exhaustive exercise.
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