Advances in the Molecular Mechanism and Treatment of Maternal Diabetes-Induced Embryonic Neural Tube Defects
CAI Shufang, ZHOU Mei, WANG Bingbin, ZHENG Guowei, ZHANG Yiwei, ZHONG Haodong, WU Yanqing*
NTDs (neural tube defects) is one kind of serious congenital malformation, which is caused by the inability or incomplete closure of neural tube during embryonic development. Maternal diabetes significantly increases the incidence of NTDs in embryos. Maternal diabetes can induce the molecular mechanisms of oxidative stress, ERS (endoplasmic reticulum stress), impaired autophagy, excessive apoptosis and cell senescence in embryos, and ultimately lead to abnormal neural tube closure in embryos. Current paper will describe the research progress on the mechanism and treatment strategies of maternal diabetes-induced embryonic NTDs, and provide a theoretical basis for the clinically prevention and treatment of maternal diabetes-induced embryonic NTDs.
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