The Role of NMDA Receptor in the Occurrence and Development of Anxiety Disorder
ZHANG Fan1, 2, SHU Yuqian1, 2, WU Fan1, 2, LU Jiao1, 2, WANG Qing1, 2, ZHAO Hang1, 2, HE Zhi1, 2*
With the increasing pressure of social life, anxiety has gradually become one of the most common mental diseases. The pathogenesis of anxiety disorder involves the regulation disorder of many system functions, and many brain areas of human participate in the occurrence of anxiety. NMDA receptor is a polymeric complex composed of seven different subunits that mediate excitatory neurotransmission in the central nervous system, and its different subunits play an important role in the pathogenesis of anxiety disorders. In addition, studies in animal models of anxiety disorders have shown that NMDA receptors are involved in the generation of anxiety by influencing fear conditioning and fear extinction. This article aims to review the expression levels of different NMDA receptor subunits and their downstream signaling pathways in anxiety disorders, as well as the research progress of NMDA receptor related drugs in the treatment of anxiety disorders, such as ketamine, memantine and D-cycloserine.
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