Non-Coding RNAs in Cardiomyocyte Proliferation and Cardiac Regeneration

DONG Xiaoxuan^1,2#, PU Linbin^1,2#, CHEN Jinghai^1,2*

（¹Provincial Key Lab of Cardiovascular Research, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; ²Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, China)

Abstract:

Myocardial infarction is associated with high incidence and mortality, which seriously impacts on human health and places a heavy economic burden on countries worldwide. Stimulating cardiomyocyte proliferation and cardiac regeneration is a key to repair the injured heart caused by ischaemia. Emerging evidences have demonstrated that non-coding RNAs play important roles in cardiac proliferation and regeneration. This review focuses on the function and mechanism that miRNAs (microRNAs), lncRNAs (long non-coding RNAs) and circRNAs (circular RNAs) modulate cardiomyocyte proliferation and regeneration to mend a damaged heart. Furthermore, the potential therapeutic roles of these non-coding RNAs in boosting cardiomyocytes proliferation is highlighted. Finally, this review presents the perspective on the development of non-coding RNA therapy in heart diseases by regeneration.

CSTR: 32200.14.cjcb.2022.08.0007