Regulation of Shh Signaling Pathway on the Development and Renewal of Tongue Taste Buds and Tongue Cancer
ZHONG Fengbo, WU Linna, CHEN Yajuan*, WANG Bingmei*
Shh (sonic hedgehog) signaling pathway is one of the Hedgehog signaling pathway family. During the development of mammalian organs, Shh signaling pathway controls cell fate, proliferation and differentiation. Tongue taste buds are mainly located on the dorsal of the tongue and are the bearers of taste perception. Tongue taste buds have 4 different types of taste cells. Shh signaling pathway plays an important regulatory role in the early development of tongue taste buds and the renewal of adult taste buds. The abnormal expression of key factors of this signaling pathway can lead to defects in tongue taste papilla development and abnormal taste bud function. At the same time, when the signal pathway is abnormally activated, it will cause the occurrence and development of adult tongue tumors. This paper mainly expounds the regulatory role of Shh signaling pathway on the development and renewal of taste buds in mammalian tongue and the occurrence and development of tongue cancer.
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