Mechanism of Autophagy Flux Disorder in Nerve Injury after Ischemic Stroke
LIU Yili, LIU Yuyuan, HUANG Zhiwen, HE Hongyun*, DENG Yihao*
Autophagy is a catabolic pathway, which degrades long-lived or misfolded proteins and damaged organelles in order to maintain homeostasis and normal cell function. Contrarily, if autophagy flux is disturbed, it may affect the degradation of intracellular proteins and organelles, disrupt cell homeostasis, and ultimately lead to the death of neurons. Studies have shown that ischemic stroke may induce brain injury primarily by energy consumption, oxidative stress and inflammation, which are significantly correlated with changes in autophagy flux of neurons after stress. This article reviews the mechanism of autophagy flux disorder after ischemic stroke and its related therapeutic drugs and methods.
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