Gender Differences that Cannot be Ignored—an Exploration of the Field of Pain

LU Zhongyun¹, PAN Weizhou², JIN Hua^1,3*

(¹Medical School, Kunming University of Science and Technology, Kunming 650500, China; ²Department of Anesthesiology, the First People’s Hospital of Yunnan Province, Kunming 650032, China)

Abstract:

Gender difference is a widespread and ignored problem in scientific research. This difference is particularly obvious and important in the field of medical research. In real life, almost everyone has experienced or is experiencing pain, so gender differences in pain have received more attention than in other medical disciplines. This article will discuss the gender differences in pain mechanisms from the perspectives of genetics, neuroimmunology, molecular biology, and social psychology; and describe the importance of gender in biological variables. It emphasizes the non-negligibility of gender differences in preclinical and clinical researches, and provides a basis for the development of pain treatment and related basic research.

CSTR: 32200.14.cjcb.2022.06.0028