Research Progresses of PLA2R Epitope and Its Antibody in Idiopathic Membranous Nephropathy
ZHENG Tianyu, HUANG Biao, ZHOU Xiumei*
IMN (idiopathic membranous nephropathy) is an autoimmune disease and one of the main clinical causes of nephrotic syndrome in adults. The main reason for its occurrence is the increase of the protein with very low content in the body, such as PLA2R (M-type phospholipase A2 receptor), have an impact on the filtration of the kidney’s membrane, causing a series of immune responses of the body. This article mainly introduces the research on IMN serum markers, PLA2R antigen and antibody in recent years, especially the research on the PLA2R epitope, and integrates the correlation information between the changes of PLA2R epitope and the stratified prognosis of IMN. It is hoped that through the integration of known information, future research directions for the diagnosis and treatment of IMN can be explored.
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