Dual Specificity Phosphatase 6 in Tumor Development and Glucose and Lipid Metabolism

SUN Jialei¹, LIANG Xiaodi², GUAN Yangyang¹, LIU Xiaomin¹, PANG Ziyan¹, ZHAO Yifei¹, WANG Yan¹*

(¹Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China; ²State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830002, China)

Abstract:

DUSP6 (dual specificity phosphatase 6), which is widely expressed in human tissues, is a member of the DUSP (dual specificity phosphatase) family that dephosphorylates ERK1/2 (extracellular signal-regulated kinase 1/2) specifically. Due to its negative regulation in the MAPK (mitogen-activated protein kinase) signaling pathway, it has been shown to play an essential role in tumor proliferation, tumor resistance or drug sensitivity to chemotherapy, tumor diagnosis, metabolic homeostasis, which provides new ideas for drug target development. However, the effect of DUSP6 on tumors and glucose and lipid metabolism is diverse and partly contradictory. This delays the process of DUSP6 benefiting humanity. The present review will summarize the current knowledge of DUSP6 in different tumor and metabolic models, discuss the potential reasons for this contradiction, and try to give some solutions. This paper will also summarize its underline molecular mechanisms and potential translational applications.

CSTR: 32200.14.cjcb.2022.06.0024