The Role of Exosomes in Wound Healing
CHEN Fengjiao1, LÜ Jiahui1, ZUO Zhaoyan1, YANG Ying1, HUANG Jinwei1, LU Ying2, DING Jie1*
Wound healing is a complex and coordinated process affected by multiple endogenous and exogenous imbalances. Intercellular communication is necessary for wound cell development and maintenance of wound microenvironment homeostasis. Exosomes are extracellular vesicles that have received special attention for their regulatory functions in many biological processes in recent years, which can be isolated from almost any cell, participate in intercellular communication, and participate in normal and pathobiological mechanisms. The collection or composition of exosomes contributes to cell communication around wound. Exosomes rich in lipids and proteins mediate the stages of wound healing such as coagulation, inflammation and angiogenesis to regulate specific immune responses of the body. Therefore, exosomes can help to reconstruct the integrity of tissues. This paper reviews the structure and function of exosomes and their molecular dynamics involved in various stages of effective wound healing, in order to evaluate the factors and potential ways that exosomes may accelerate the process of wound healing, and to clarify the role of exosomes and their contents in different cells and different signaling pathways.
CN
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