Progress of Ferroptosis Mechanism and It’s Application in Hematological Diseases
ZHENG Suying, FANG Zehao, JIN Jing, LI Dan, FENG Weiying*
Ferroptosis is a newly discovered form of PCD (programmed cell death), which is the link between metabolism, redox biology and human health. It is characterized by lethal accumulation of lipid ROS (reactive oxygen species) and is iron-dependent. Ferroptosis is different from several other traditional cell death forms, such as necrosis, apoptosis and autophagy in morphological, biochemical and genetic mechanisms. Ferroptosis was initially found in tumor cells. However, with the deepening of the study of ferroptosis, it has been found that ferroptosis is also closely related to hematological diseases in recent years, such as leukemia, lymphoma, MM (multiple myeloma), MDS (myelodysplastic syndromes) and anaemia diseases. This paper reviews the research progress on the mechanism of ferroptosis and its role in hematological diseases, so as to provide new theoretical basis and strategies for the diagnosis and treatment of clinical hematological diseases.
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