Research Progress of Exosomal miRNA in the Treatment of Ischemic Stroke

CHAI Miao¹, SU Gang², GAO Juan¹, CHEN Wei¹, DONG Ying¹, WANG He¹, GAO Xin¹, ZHANG Zhenchang¹*

(¹Department of Neurology, Lanzhou University Second Hospital, Lanzhou 730030, China; ²Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China)

Abstract:

The neurological dysfunction caused by ischemic stroke brings heavy economic burden to society and families. However, the specific clinical therapy for ischemic stroke is still lacking at present. Exosomes have good compatibility and can cross the blood-brain barrier easily. At the same time, exosomes can transfer contents to recipient cells, and then affect the biological function of recipient cells, which may provide a new treatment method for ischemic stroke. As a part of exosome contents, miRNA has attracted much attention. This article reviews the research progress and the potential of targeted delivery of exosomal miRNA in the treatment of ischemic stroke, so as to provide reference directions for future research and the selection of therapeutic targets for ischemic stroke.

CSTR: 32200.14.cjcb.2022.06.0020