Effect and Mechanism of Exercise Intervention in Alzheimer’s Disease Induced by Diabetes
JIN Meng1, MU Shuaimin1, LI Chunyan2, CHEN Ning2, KOU Xianjuan2, QIAN Shuaiwei2*
Epidemiological studies have shown that the incidence of AD (Alzheimer’s disease) in patients with diabetes is significantly increased, suggesting that diabetes may play a key role in the development of AD. In addition, diabetic encephalic insulin signal abnormalities, neuroinflammation, oxidative stress, mitochondrial dysfunction, vascular dysfunction and other pathogenic factors can lead to amyloid-β accumulation and Tau phosphorylation through a variety of ways, accelerate nerve cell death, and further aggravate cognitive dysfunction and promote the occurrence of AD. In recent years, it has been found that a variety of anti-diabetes drugs can improve the efficacy or effect of AD to varying degrees. Exercise can also improve the pathological changes related to AD caused by diabetes by alleviating neuroinflammatory state, inhibiting oxidative stress and mitochondrial dysfunction, improving endothelial function and cerebrovascular dysfunction, and inducing neurogenesis. Therefore, this review will summarize the pathological mechanism of diabetes-induced AD and the prevention and treatment mechanism of some antidiabetic drugs, and explore the intervention effect and mechanism of exercise in improving diabetesinduced AD, in order to provide more theoretical reference for the diversity of its treatment.
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