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Role of Synovial Fibroblasts in the Pathogenesis of Rheumatoid Arthritis
Ya-Nan Hou, Li-He Guo*
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiopathogenesis. One of the hallmarks of RA is the hyperplastic growth of synovial tissue， which serves as both the propagator of abnormal immune response and the engine of tissue damage. In recent years， accumulating evidence has indicated that activated and hyperproliferating synovial fibroblasts drive both inflammation and autoimmunity， and are directly responsible for joint destruction in RA. In this article， we review the current studies that implicate the synovial fibroblasts as a key player in the initiation and propagation of RA disease.
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