Recent Advances in Lipid Droplet-Organelle Interactions
CAI Lipeng, KANG Na, TAN Jinling, QIU Fan, GAO Qiang*
Organelles contact and collaborate to accomplish the material transfer and signal communication. LDs (lipid droplets) are the main neutral lipid storage organelles, but their functions are far more than that. LDs can interact with various organelles including the endoplasmic reticulum, mitochondria, peroxisomes, lysosomes/vacuoles, and nucleus, to jointly achieve functions such as lipid metabolism, membrane transport, and signal transduction. In this review, the latest research progress on the contacts and dynamic interactions between LDs and other intracellular organelles was summarized. The study of interaction mechanism and function between LDs and intracellular organelles can not only broaden the knowledge of lipid droplet biology, but also can further the understanding of the pathogenesis of metabolic diseases.
CN
EN