Research Progress in the Role of HCN Channel in Anxiety

WANG Qing^1,2, ZHAO Hang^1,2, WU Fan^1,2, SHU Yuqian^1,2, ZHANG Fan^1,2, LU Jiao^1,2, HE Zhi^1,2*

( ¹ Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; ² Medical College, China Three Gorges University, Yichang 443002, China)

Abstract:

HCN (hyperpolarization-activated cyclic nucleotide-gated) channels have important physiological functions, especially in aspects of resting membrane potentials, dendritic integration, neuronal pacing and the establishment of action potential thresholds. Studies have found that the disorder of this channel may cause anxiety. The mechanism of HCN channel mediated anxiety may be affected by BDNF (brain-derived neurotrophic factor)/ mTOR (mammalian target of rapamycin), Glu (glutamate), GABA (γ-aminobutyric acid), monoamine neurotransmitters, synaptic plasticity, etc. This article reviews the structure, distribution, regulation and possible mechanisms of HCN channels that mediate anxiety, and provides drug treatment targets for the prevention and treatment of anxiety

CSTR: 32200.14.cjcb.2022.05.0020