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Research Advance in Anti-Tumor Targets of Chalcone Compounds
WANG Zhiyao, LIU Xifu*, CHEN Jing*
(College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China)
Abstract:
Chalcone is a natural compound, which is an active ingredient in a variety of medicinal plants, and its anti-tumor activity has been successively reported at home and abroad. Chalcone compounds have a wide range of anti-tumor targets, but there is a lack of systematic literature review. Therefore, the article reviews chalcone compounds as potential anti-tumor drugs to inhibit IκB kinase, thioredoxin reductase, tubulin, vascular epidermal growth factor and p53 pathway in order to provide more theoretical reference for tumor treatment.