Research Progress on the Mechanism of miR-21 in Osteoarthritis
ZHOU Xuchang, CHEN Yan, HUA Weizhong, NI Guoxin*
OA (osteoarthritis) is a chronic degenerative joint disease that occurs in the elderly. There is no effective treatment that can completely reverse the progression of OA due to its complicated pathogenesis. With the aging of the population, the number of OA patients has gradually increased, bringing a heavy economic burden to their family and society. Therefore, it is of great significance to clarify the pathogenesis of OA in depth and find effective early molecular diagnostic markers or potential therapeutic targets. miRNA (microRNA) is a non-coding RNA that has been studied in recent years. A large number of studies have shown that miR-21 plays an important role in both OA cartilage degradation and joint pain. In this article, by consulting the related literatures of miR21 and OA, the roles of lncRNA, MMPs, GDF-5, FGF and TLR7 in the process of miR-21 regulating OA were explored, and the specific regulation mechanisms of miR-21 on OA were summarized, so as to provide a basis for exploring early molecular diagnostic markers and potential therapeutic targets of OA.
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