Recent Progress in Endocrine Function of Brown Adipose Tissue

CHEN Wei^1,2,3,4, LIU Jiaqi^1,2,3,4, LIU Yuxi^1,2,3,4, WANG Xinxia^1,2,3,4*

( ¹ College of Animal Sciences, Zhejiang University, Hangzhou 310058, China; ² Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, Hangzhou 310058, China; ³ Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou 310058, China; ⁴ Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Hangzhou 310058, China)

Abstract:

As a conventional thermogenic organ, BAT (brown adipose tissue) is associated with obesity, type 2 diabetes, non-alcoholic fatty liver disease and other metabolic diseases. Current studies have found that BAT not only participates in energy metabolism, but also has endocrine function. BAT can regulate systemic tissues/ organs by secreting lipid factors (batokine). Further studies on the regulatory effect of BAT on other tissues/organs will enable more effective therapeutic strategies for the treatment of metabolic diseases. Therefore, this review summarizes the endocrine function of BAT with the hope to provide a theoretical basis for targeting BAT-mediated systemic regulation

CSTR: 32200.14.cjcb.2022.05.0017