Advances in the Research of New Hepatocytes Origin in Different Liver Injury Models
LI Ting, YANG Jinshu, YANG Weijun*
The liver is a unique organ that performs many vital physiological functions. It possesses a remarkable regenerative capacity that can restore normal volume rapidly after injury. The capacity for repair is largely attributable to the ability of its differentiated epithelial cells, including hepatocytes and biliary epithelial cells, to proliferate after injury. However, in cases of extreme acute injury or prolonged chronic insult, the liver may fail to regenerate or do so suboptimally. Many studies have demonstrated that different liver-damage models mobilize different subtypes of hepatic epithelial cells in contributing to liver regeneration. This review discusses five hepatic injury models, and the origin of new hepatocytes, cellular plasticity within the epithelial cells under these circumstances, which will provide reference for future research and disease treatment.
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