The Structure and Fuction Progress on Transmembrane Serine Protease 2
QI Lulu1, BAO Haiyue1, LIN Congmei1, JIANG Huilin1, DA Zheng1, LU Xinke1, LOU Meiqi1, ZHANG Manyu1, WU Li1 *, FENG Huapeng2 *
TMPRSS2 (transmembrane serine protease 2) plays a key role in human diseases. Firstly, TMPRSS2 can promote the occurrence and development of cancer, including prostate cancer, lung cancer and colorectal cancer. Secondly, TMPRSS2 can stimulate the activation of virus particles and enhance infectivity in mediating the infection of virus, including influenza virus, coronavirus and rotavirus. Studies have shown that TMPRSS2 can promote the invasion process of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). Therefore, in view of the important role of TMPRSS2 in physiology and pathology, then from this article summarizes the current progress on the structure, function and influence of TMPRSS2 based on the related publications. This work will provide important reference for the future research on TMPRSS2, including the development of new drugs and vaccines targeting TMPRSS2.
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