Characterization of RNF11 and Progress of It’s Research in Malignant Tumors
WEI Cheng, LÜ Bingzhe, MA Dongjiang, FAN Yong, KANG Boxiong, WANG Chen*
Members of the ring finger protein family are involved in the regulation of a variety of cellular activities and are key regulators in the development of disease. RNF11 (ring finger protein 11), a 154-amino acid residue protein, is a member of the ring finger family of proteins that has attracted widespread interest. RNF11 plays an important role in cell signaling and transcription factor regulation, particularly in the EGFR, TGF-β and NF-κB pathways, and is closely associated with the development of malignant tumors. It is closely associated with the development of malignant tumors. Although RNF11 has been shown to be overexpressed in human prostate, colon and invasive breast cancers, its role as a tumor growth suppressor or promoter remains controversial. This paper reviews the structure and main biological functions of RNF11 and its role in malignant tumorigenesis and metastasis, and provides a theoretical basis for further research on therapeutic method and targeted drugs for related diseases.
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