Roles of STRIPAK Complex in Tumorigenesis
CAO Zhifa1, TANG Yang2, NIE Pingping1, HAN Yi2, ZHOU Zhaocai3*, AN Liwei2*
The STRIPAK (striatin-interacting phosphatase and kinase) is a class of supramolecular complexes conserved in different organisms. Functionally, STRIPAK complexes play essential roles in several biological processes ranging from cell proliferation, apoptosis, vesicle transport to cell cycle regulation. Thus, STRIPAK has been shown to participate in regulating organ development, tissue homeostasis, and immune modulation. Of note, STRIPAK can be assembled into diverse forms and compositions in response to extracellular or intracellular stimuli, dysregulation of which, via either subunit expression or complex formation, is closely related to diverse human diseases including cancer. Here by reviewing the recent advances in understanding the topological structure, signal transduction networks, as well as the physiological and pathological roles of STRIPAK, this paper aims to provide novel insights into understanding of tumorigenesis and targeted strategy for clinical anti-tumor therapy.
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