The Shiny “Dark Matters”—Encodable Non-Coding RNA
ZHANG Shenghua, CHEN Xiaoyue, GUO Binbin, ZHOU Yifeng*
NcRNAs (non-coding RNAs), which do not encode proteins, have been considered as the ‘dark matter’ of the genome. However, a large number of new discoveries have revised this view: miRNAs (microRNAs), circRNAs (circular RNAs) and LncRNAs (long non-coding RNAs) all have sORFs (small open reading frames), which can encode functional micropeptides or proteins. This review summarizes the researched ncRNA-encoded peptides according to their different functions, and expounds on the research methods and functional mechanisms of these ncRNA-encoded peptides, so that these shiny “dark matters”—ncRNA-encoded peptides can attach the attention of scholars in different research fields.
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