Research Progress on the Role of DNA Damage Response Pathway in Tumorigenesis and Treatment

LI Yunhui¹, LI Lei¹, WANG Xinshu¹, CAO Yueyu^1,2, HUANG Zhiyuan¹, YANG Yuntong^1,2, WANG Li^1,2, YUAN Jian^1,2*

(¹Research Center for Translational Medicine, East Hospital Affiliated to Tongji University, Shanghai 200120, China; ²Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200331, China)

Abstract:

Maintaining genomic stability is very important to maintain the normal work of human organs. Biological organisms are attacked by various DNA damage factors all the time. Endogenous factors such as free radicals and exogenous factors such as ionic radiation and ultraviolet can injure cell genomic DNA. The human body has a set of response mechanisms to deal with DNA damage. DNA damage activates cell cycle checkpoint, blocks cell cycle temporarily and starts cells to repair damaged DNA. If the damage cannot be repaired, it will cause apoptosis. The defect of DNA damage response system can lead to genomic instability and mutation, which can induce tumor. This paper reviews the current research status of DNA damage repair, tumor occurrence and tumor treatment, and puts forward a new prospect of tumor treatment, looking forward to provide reference for exploring new tumor targets and tumor treatment.

CSTR: 32200.14.cjcb.2022.04.0018