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Regulation of Metabolism during Tumor Metastasis
QI Yijun1, GAO Hong2, LIU Chen2, YANG Weiwei1,2*
(1School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310000, China; 2Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China)
Abstract:
Metastasis is the primary cause of 90% of cancer-associated death. Compared with primary tumor, metastatic tumor displays distinct metabolic traits. It has been shown that those metabolic dysregulations play a crucial role in migration, invasion, anti-anoikis and metastatic colonization of tumor cells. Thus, better understanding of the mechanism underlying metabolic reprogramming during metastasis helps to identify metabolic vulnerabilities in tumor cells to dampen metastasis, thereby providing the effective therapeutic strategy for metastatic cancer.
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