Key Enzymes in Glucose and Lipid Metabolism and Their Functions in Tumor Cell Proliferation
JIN Xin1,2, WANG Yang1,2, FENG Yunpeng1,2, WEI Min1,2*
In recent decades, metabolic enzymes have attracted a tremendous amount of attention due to their central role in the control of tumor cell metabolism. Specific enzymes can change their enzymatic activity through multiple manners, including abnormal expression, gene mutation, post-translational modification, and altered oligomerization and sub-cellular localization. Sometimes, they can also function as non-metabolic enzymes to regulate different cellular events. This review focuses on enzymes involved in glucose and lipid metabolism in rapidly proliferating tumor cells, and emphasizes biological consequences from alterations in their activity and function. By discussing the three basic needs of tumor cells: increased biosynthesis of macromolecules, high demand of energy and balanced cellular redox status, this review will provide insights into tumor-associated research and therapeutic treatments against cancers.
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