Tertiary Lymphoid Structure and Antitumor Immunity
WENG Xiaoqi, SU Shicheng, LU Yiwen*
TLSs (tertiary lymphoid structures), also known as ELOs (ectopic lymphoid organs), are organized aggregates of immune cells that localize in non-lymphoid tissues at sites of chronic inflammation, such as autoimmune diseases, infectious diseases and tumors. The structure of TLS is similar with that of lymph node, which composes of T cells, B cells, follicular dendritic cells, etc. TLS serves as an entry for immune cells to infiltrate in tumor tissues. The presence of TLS commonly correlates with a better therapeutic response and a longer survival. Here, this article reviewed the composition, structure, function, the role of TLS in tumor prognosis and therapeutic strategies targeting TLS.
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