The Effects of Adipose-Derived Mesenchymal Stem Cells on Breast Cancer Progression
DONG Haonan, LIU Suling*
Obesity can cause a variety of malignant diseases including cancer. Epidemiology shows that excessive obesity will increase the risk of breast cancer and worsen the prognosis. Adipose tissue dysfunction in obese patients is characterized by hypertrophy and hyperplasia of white adipose cells. Adipose-derived mesenchymal stem cells are a kind of mesenchymal stem cells isolated from white adipose tissue, which have strong proliferation and differentiation abilities. As a potential tumor promoter of breast cancer cells, adipose-derived mesenchymal stem cells support tumor progression and invasion by activating multiple intracellular signals. However, there are conflicting reports on the interaction between adipose-derived mesenchymal stem cells and breast cancer cells, and the possible molecular mechanisms remain to be further explored. This review will focus on recent studies on the effects of adipose-mesenchymal stem cells on breast cancer progression, with the aim of providing novel strategies for breast cancer therapy.
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