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Extracellular Vesicles and Cancers
XIAO Beibei#, GAO Ying#, LIN Yujie, ZHENG Xueping, CHEN Yilin, KANG Tiebang*
(Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou 510060, China)
Abstract:
EVs (extracellular vesicles) (including exosomes, microvesicles, apoptotic bodies, migrasomes, retractosomes, R-EVs, etc.) secreted by cells contain DNA, RNA, secreted proteins, lipids, membrane receptors and other types of bioactive macromolecules. It plays a key role in cell plasticity, intercellular communication and microenvironment modification. This review summaized the types, formation, regulation of extracellular vesicles and their roles and clinical significance in tumorigenesis, metastasis, tumor immunity and targeted therapy.
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