Home > Browse Issues > Vol.44 No.4
Programmed Cell Death and Tumor
WANG Fang1,2#, LI Kaiying1,2#, CAI Zhenyu1,2*
(1Cancer Center, Tenth Peoples Hospital of Tongji University, Shanghai 200070, China; 2Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200092, China)
Abstract:
PCD (programmed cell death) is a genetically regulated process leading to the death of cells. It plays a critical role in organismal development, homeostasis, and pathogenesis. Necroptosis, ferroptosis and pyroptosis are recently identified PCDs with necrotic morphology. Unlike apoptosis, these types of PCDs induce inflammatory responses in vivo. In this review, the role of the multiple types of PCDs in tumorigenesis will be discussed, in order to provide new ideas for further study of tumor pathogenesis and development of related anti-tumor drugs.
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