The Role of Protein SUMOylation in Cancer
CAI Rong*, CHENG Jinke
As an important protein post-translation modification, SUMOylation regulates stability, subcellular localization and activity of its substrates during numerous cellular biological processes, including cell cycle progression, cell metabolism, gene transcription, and DNA damage & repair. SUMOylation is a dynamic and reversible process, with de-SUMOylation mediated by SENPs (SUMO-specific proteases). The regulation of SUMOylation in cancer is complicated, owing to the varieties and multiple functions of its substrates. On global level as well as on individual protein level, SUMOylation regulates cell cycle progression, genome instability and cellular metabolism in tumor cells, and antitumor activity in immune cells, which thereby is greatly involved in tumoreigenesis and tumor progression. By removing SUMOs from specific substrates, SENPs chiefly decides the SUMOylation level of its targets. In this review, based on the studies of our lab for years, the biological roles of SENP1 and SENP3 in cancer will be introduced as well.
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