Research Progress on Deubiquitinases in Bacteria and Their Biological Functions
WANG Huannan1,2, ZHEN Xiangkai1, ZHANG Dandan1, OUYANG Songying1,2*
In the process of bacterial infection, the host cells can make use of their own ubiquitin system for immune responses. In the co-evolution of host and bacteria, bacteria can encode deubiquitinases to target the host ubiquitin system and reduce the host inflammatory signal response, which is conducive to the survival and reproduction of bacteria. This article comprehensively introduced the bacterial deubiquitinases that had been discovered so far and summarized the bacterial deubiquitinases according to the classification. The cleavage specificities and biological function of OTU family deubiquitinases and CE family deubiquitinases were described in detail. In addition, deubiquitinases with special catalytic activity were also introduced. In-depth study of the molecular mechanism of deubiquitinases will help to understand their biological functions, which can provide information for the development of new therapeutic drugs and anti-infection vaccines.
CN
EN