Progress of Dendritic Cell under Hypoxic Microenvironment

ZHANG Leiting^1,2, YU Jing¹*, XIA Yu¹, LIU Ke^1,2, LI Suiyan², YAN Jun¹*

（ ¹State Key Laboratory of Trauma, Burns and Combined Injury, Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Department of Special War Wound, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing 400042, China; ²School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China)

Abstract:

Hypoxic microenvironment is resulted from many factors, such as embryogenesis, life on the plateau, physical exercise, severe trauma, cardiovascular disease and tumor, and leads to the characteristic changes of physiology and pathology. Moreover, hypoxic microenvironment may influence immunity function via immunocytes directly. DC (dendritic cell) is not only the strongest APC (antigen presenting cell) in vivo, but also a “bridge” between innate immunity and adaptive immunity. However, the roles of DC are not coincidental in different microenvironments. Thus, the biological functions of DC in differentiation, apoptosis, migration, antigen presenting and related gene expression under hypoxic microenvironment are reviewed in this paper.

CSTR: 32200.14.cjcb.2022.02.0016