The Impact of cGAS-STING Signal Pathway in Cardiovascular Diseases

XIANG Qizhong ¹, ZHANG Qinghai^1,2*, ZHENG Zhaofen^1,2*

( ¹Department of Cardiology, the First Affiliated Hospital of Hunan Normal University (Hunan Provincial People’s Hospital), Changsha 410000, China; ²Clinical Medicine Research Center of Heart Failure of Hunan Province, Changsha 410000, China)

Abstract:

cGAS (cyclic GMP-AMP synthase) is a DNA sensor that generates cGAMP (cyclic GMP-AMP) by recognizing cytoplasmic DNA, which subsequently activates the STING (stimulator of interferon gene) and a series of downstream pathways to mediate immune and inflammatory responses. In recent years, emerging evidences show that cGAS-STING signal pathways are significantly activated in a variety of cardiovascular diseases such as myocardial infarction, heart failure and myocarditis, suggesting that it may play an important role in the pathogenesis of cardiovascular diseases. To further understand the functions of cGAS-STING signal pathways in cardiovascular diseases, this article summarizes the biochemical characteristics of cGAS and the role of cGAS-mediated signal pathways in cardiovascular diseases.

CSTR: 32200.14.cjcb.2022.02.0014