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MS-Based Blood Proteomics: Emerging Research Focus in Hematology
FU Lixia#, CHENG Ziqian#, WANG Hong*, NIU Mingming*
(State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China)
Abstract:
With cutting-edge MS (mass spectrometry)-based proteomic technologies (e.g. single-cell proteomics) getting mature nowadays, their application in hematology is quickly expanding. This article briefly introduces MS-based proteomics, then reviews recent progress in blood proteomics, and further comments on the technological improvements of plasma/serum proteomics and the potential of extracellular vesicle proteomics. Finally, the future development of clinical blood proteome is prospected. Clinical blood proteomics will certainly become a research focus in near future.
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