Research Progress on the Pathogenesis of Prolonged Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation
SHEN Biao, PANG Aiming, JIANG Erlie
PT (prolonged thrombocytopenia) is a common complication after allogeneic hematopoietic stem cell transplantation, with an incidence of about 5%-37%. PT occurred in the transplant patients not only increases the risk of bleeding, but also is closely related to poor prognosis. Previous retrospective studies have shown that the toxicity of conditioning drugs before transplantation, the number of CD34+ cells infused, graft-versus-host disease and infection after transplantation are the important causes of PT. However, with the continuous progress of research, more and more evidences show that PT is closely related to the disturbance of hematopoietic stem and progenitor cell differentiation, abnormal bone marrow cell microenvironment and enhanced bone marrow immune function. This article mainly reviews from the above aspects, in order to reveal the possible mechanism of PT and provide theoretical basis for effective clinical treatment of PT.
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