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Bone Marrow Microenvironment of Hematological Malignancies
WANG Kefei, ZHENG Wenting, YUAN Jiapei, WEI Jun*
(State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China)
Abstract:
Genetic and epigenetic lesions within hematopoietic cell populations can drive the development of hematological malignancies. However, emerging studies have revealed crucial roles of bone marrow microenvironment in the initiation, progression and chemoresistance of hematological malignancies. This review summarized recent findings on how bone marrow microenvironment organized in steady state and re-shaped in hematological malignancies and its impact on disease outcomes, highlighting the implications for the therapeutic targeting of immunosuppressive bone marrow microenvironment.
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