Immune Imbalance in Immune Thrombocytopenia
WANG Xiyan, LI Huiyuan*, YANG Renchi*
ITP (immune thrombocytopenia) is an autoimmune bleeding disease in which multiple immune-related mechanisms are involved. Anti-platelet antibody produced by B cells to mediate platelet phagocytosis by macrophages is considered to be the classic pathogenesis of ITP. The imbalance of cellular immunity mediated by T cell subsets and related cytokines is gradually confirmed in ITP. In addition, the role of immune microenvironment disorders caused by the imbalance of immune cells such as antigen-presenting cells and mesenchymal stem cells, abnormal gene expression, infection, metabolism in the pathogenesis of ITP has gradually received attention. This study intends to review the immune mechanism of ITP and related research.
CN
EN