Current Progress in Thrombopoiesis
HUANG Baiming, LIU Cuicui, ZHAO Jingjing, WANG Hongtao, ZHOU Jiaxi*
Thrombopoiesis, the maturation process of platelets released by mature megakaryocytes, is the last part of platelet generation in the peripheral blood. Currently, with the deepening understanding of platelet functional diversity and the need of efficient generation strategy, it is important to have a comprehensive cognition of thrombopoiesis. While past researches tend to focus on the differentiation of hematopoietic stem/progenitor cells and megakaryocytes, very little attention has been paid to the process of thrombopoiesis. In this paper, the changes of platelet morphology, RNA content and variety, as well as the molecular features and functions during thrombopoiesis were systematically reviewed. It will provide new insights into the platelet functional diversity, transcriptome heterogeneity and in vitro generation strategies.
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