Effect on Biological Function of Mesenchymal Stem Cells Cultured in Vitro
CAO Yangjia, PENG Xuemei, ZHANG Yingchi, CHENG Tao*
Mesenchymal stem cells are the most widely used high-quality regenerative medicine resources, which are extremely suitable for clinical research and application due to their lack of problems such as matching and rejection. Amplification in vitro is necessary to meet the large demand for clinical applications. However, with the increase of passages cultured in vitro, mesenchymal stem cells will produce many biological changes. This review illustrated the cellular and molecular characteristics and functional changes of mesenchymal stem cells that have been continuously passed in vitro, aiming to establish further optimization of cell therapy and to provide theoretical reference for the research.
CN
EN