Roles of Chemokine CCL3 in Pathologic Pain and Opioid Tolerance
LI Fengjiao, SHI Yonghui, WANG Dongmei*
CCL3 [chemokine (C-C motif) ligand 3] is a member of the chemokine family and is widely expressed in the nervous and immune systems. Studies have shown that CCL3 plays a role in the occurrence and maintenance of neuropathic and inflammatory pain by recruiting immune cells, activating intracellular signaling pathways and mediating the interaction between neurons and glial cells. In addition, CCL3 can also cause MOR (μ opioid receptor) desensitization, thus affecting the analgesic effects of morphine and participating in the formation of opioid tolerance. This paper reviews the roles of CCL3 and its receptor in pathological pain and opioid tolerance.
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