Research Progress of the Relationship between Microglia and Traumatic Brain Injury
TANG Jiaqi, LU Yunbi*
TBI (traumatic brain injury) is one of the main causes of human death and disability in the world, and there is no effective treatment at present. TBI can be divided into two stages: transient primary injury, which occurs at the moment of injury, and subsequent secondary injury. The secondary injury involves a series of complex pathological processes. Neuroinflammation is a symbol of TBI, which is considered as a major factor in determining disease progression and outcome. Microglia, as the first and most important immune defense line in the central nervous system, is activated rapidly after TBI, and shows dynamic phenotype in response to the changes of brain microenvironment. Microglia has dual effects of neuroprotection and neurotoxicity. Therefore, microglia is regarded as an important target for the treatment of TBI. Here, the temporal and spatial characteristics, function of microglia after TBI and the research progress of microglia-targeted therapy are reviewed.
CN
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